By Takeo Mizutani, M.D., Institute of Physical and Chemical Research

How does SEIGEN exert its effect on the body? Although we have insufficient experimental data to provide a complete answer to this question, I will share here my own belief based on my studies and observations.

Our body normally functions by virtue of the regulatory mechanisms that maintain homeostasis (a stable condition). Once the function of any key regulatory mechanism deteriorates due to stress, metabolic malfunction, infection, aging, etc., homeostasis can no longer be maintained. This results in metabolic, inflammatory, and immunological conditions and challenges.

The regulatory mechanism that maintains homeostasis is controlled by neural transmission and by signaling molecules produced by cells in the nervous, endocrine and immune systems. It is likely that SEIGEN is actively involved in these regulatory mechanisms, thereby augmenting the natural power of the body to counteract challenges to health.

SEIGEN contains Muramyl Dipeptide, a body constituent of lactic acid bacteria and yeast. Muramyl Dipeptide is known to act on macrophage cells and glial cells in the brain to stimulate cytokine release, which in turn regulates sleep by itself or through its actions on the nervous and endocrine systems. Such a mechanism hints at the connection between SEIGEN and the brain.

Moreover, several cases have been reported in which SEIGEN improved the conditions of various health challenges. This suggests that SEIGEN might have some effect on brain regions such as the cerebral cortex and the limbic system that have higher cognitive functions then the hypothalamus.

The relationship of SEIGEN to the autonomic nervous system is also of great interest. The autonomic nervous system consists of the sympathetic and parasympathetic systems, which control the functions of various organs in an antagonistic manner. The parasympathetic nervous system becomes dominant under depressed conditions while the sympathetic nervous system predominates under stressful conditions.

Dr. Tory Abo at Niigata University discovered that lymphocytes express receptors for acetylcholine, a neurotransmitter used by the parasympathetic nervous system. Lymphocytes are involved in biophylaxis by recognizing antigens and producing antibodies. When over-stimulated, however, the system can react to one’s own body, creating unfavorable conditions.

In contrast, granulocytes possess receptors for the sympathetic neurotransmitter adrenaline. Reactive oxygen species are released from granulocytes upon death, and thus when released in excess, they can damage tissues and cells.

An imbalance in the autonomic nervous system contributes to triggering and aggravating various challenges to health. It is conceivable that SEIGEN might act on the autonomic nervous system to maintain the normal function of that system.

FOR EDUCATIONAL PURPOSES ONLY